This paper mainly summarizes and discusses the construction process of the virtual simulation experiment project of "Nuclear Physics Experiment".In view of the lack of curriculum content caused by the inability to preserve radioactive sources in the experimental teaching activities of nuclear physics in universities, the Physics Experimental Teaching Center of Northeastern University has developed a comprehensive experiment of nuclear physics. This experiment project has created a new model of VR open virtual simulation experiment teaching , optimized and developed the comprehensive experiment teaching of nuclear physics. Students 'subjectivity in experimental teaching activities, cultivating students' innovative ability and scientific literacy, this teaching mode is being used in experimental teaching, and has been awarded the national virtual simulation experimental teaching project.