In order to improve college students’ information literacy and practical ability，based on Mathstudio，the application of Mathstudio in data processing of three thermal experiments is introduced．Meanwhile，the processing results are compared with those of other data processing software，demonstrating the feasibility，necessity，efficiency and convenience of using Mathstudio to improve students’ability of data processing and analysing．The thermal experiment data processing method based on Mathstudio presented in this paper enriches the application of smart phones in physics experiment data processing，which is of great significance for accelerating the research and practice of teaching informatization reform and enhancing the deep integration of students’information literacy and practical ability．