This paper introduces the specific application of Mathstudio in the ISEC science and engineering course of Inner Mongolia University for Nationalities from two aspects, namely, Mathstudio's application in linear algebra and experimentsl data processing of conceptual physics. The results show that interactive & participatory teaching methods, content designs which are close to life and have theories combined with reality, will activate students not only to improve their abilities but also to increase their interest in learning. It’s a positive attempt during the teaching reform process of our university.