The Made-in-China 2025 Strategic Plan poses new challenges to the training of multi-level applied talents. How to improve the quality of personnel training to meet the increasing social needs has become the top priority in the development of higher education. Because of the particularity of local universities, it is necessary to carry out research on improving the quality of application-oriented talents training in local universities. Based on the background of the Made-in-China 2025 Strategic Plan, taking Jilin university of chemical technology as an example, this paper intends to put forward the strategy of improving the quality of application-oriented talents training in local universities from four aspects, including specialty setting, classroom reform, experimental group and school-enterprise cooperation, and carry out practical research.