By incorporating the innovation and entrepreneurship education into pharmacology teaching, the teaching reform is conducted from the application of the reverse classroom teaching model, the cooperation with pharmaceutical companies, the construction of innovative and entrepreneurial faculty, the rebuilding of the experimental teaching model of pharmacology, the construction of pharmacology-related teaching hardware and guidance of the students' participation in innovation and entrepreneurship competitions. The results show that the reform of pharmacology teaching has stimulated students' interest in learning pharmacology, breaking the inconformity of the content and practice of pharmacology courses, and improving students' practical ability, innovation ability and scientific research ability.