Mathematics course in higher vocational colleges aims to cultivate applied talents with high-quality and their professional skills. It plays an important role in helping the student' forming abstract thinking, logical reasoning and ability of analyzing and solving problems. Under the background of the rapid development of education informatization, the decline and sharp differentiation of the overall quality of students, this paper analyzed the current reform state and teaching characteristics of mathematics course in higher vocational colleges, and explores the reform ways of the mixed teaching mode from the construction of teaching resources, teaching process and teaching platform, so as to bring out more efficient functions from education, and improve the quality of personnel cultivation. It should be practical and realistic, and has long-term guiding significance.